After directing several films for television, Egbert Van Hees co-directed the video of Madonna's single Into the Groove in 1985. Two years later, he handled the directing of the Italian leg of Madonna's Who's That Girl World Tour. In 1988 he directed the video of Lovesexi Live by Prince, while 1992 saw him direct The Yellow Shark, the video recording of one of Frank Zappa's concerts featuring the Ensemble Modern Orchestra.
With hundreds of music videos to his credit, for soloists and bands such as Rod Stewart, Bon Jovi, Ozzy Osbourne, Bryan Adams, Billy Joel, Mötley Crüe, Fleetwood Mac, Pink Floyd, the Rolling Stones, Metallica, Dave Matthews Band, Britney Spears, Michael Jackson, among many others, Wayne Isham directed his first and only feature film, 12 Bucks, in 1998.